Prof. Antonio Cambria

Full Professor of Biochemistry (retired)

Brief description:

Coordinator of the Ph.D. in biochemical and biomolecular sciences from 1983 to 1997. Director of the Institute of Biochemical and Pharmacological Sciences from 1986 to 1997. Member of the Board of Directors of the Italian Society of Biochemistry (SIB) from 1997 to 2000. Honorary member of the SIB since 2004. HonoraryPresident of the Section I.N.B.B. University of Catania since 2005. In 1990, Leader of a National Research Project on "Biolectronics". Experience in the research field regarding the relationship between structure and function of some enzyme molecules: monoamineoxidases, superoxide dismutases, polyphenol oxidases (laccases).

Publications:

• Cambria MT, Gullotto D, Garavaglia S, Cambria A. In silico study of structural determinants modulating the redox potential of Rigidoporus lignosus and other fungal laccases. JBSD. Apr 30(1): 89 - 101 (2012)
• Cambria MT, Ragusa S, Calabrese V, Cambria A. Enhanced laccase production in white-rot fungus Rigidoporus lignosus by the addition of selected phenolic and aromatic compounds. Appl Biochem Biotechnol. Feb;163(3):415-22. Epub 2010 Aug 15 (2011).
• Cambria MT, Di Marino D, Falconi M, Garavaglia S, Cambria A. Docking simulation and competitive experiments validate the interaction between the 2,5-xylidine inhibitor and Rigidoporus lignosus laccase. J Biomol Struct Dyn. Feb;27(4):501 - 10 (2010).
• Cambria MT, Minniti Z, Librando V, Cambria A. Degradation of polycyclic aromatic hydrocarbons by Rigidoporus lignosus and its laccase in the presence of redox mediators. Appl Biochem Biotechnol. Apr;149(1):1-8. Epub 2008 Feb 14 (2008).
• Librando V, Cambria A, Alparone A, Gullotto D. Computational analyses of virtual proteolytic fragments generated by naphthalene 1,2-dioxygenase. In search of native-like conformation and function. Molecular Simulation, 33(3): 231 - 237 (2007).
• De Guidi G, Ragusa S, Cambria MT, Belvedere A, Catalfo A, Cambria A. Photosensitizing effect of some nonsteroidal antiinflammatory drugs on natural and artificial membranes: dependence on phospholipid composition. Chem Res Toxicol. Feb;18(2):204 - 12 (2005).
• Vianello F, Cambria A, Ragusa S, Cambria MT, Zennaro L, Rigo A. A high sensitivity amperometric biosensor using a monomolecular layer of laccase as biorecognition element. Biosens Bioelectron. Sep 15;20(2):315 - 21 (2004).
• Ragusa S, Cambria MT, Pierfederici F, Scirè A, Bertoli E, Tanfani F, Cambria A. Structure-activity relationship on fungal laccase from Rigidoporus lignosus: a Fourier-transform infrared spectroscopic study. Biochim Biophys Acta. Dec 16;1601(2):155-62 (2002).
• Gritsch S, Guccione S, Hoffmann R, Cambria A, Raciti G, Langer T. A 3D QSAR study of monoamino oxidase-B inhibitors using the chemical function based pharmacophore generation approach. J Enzyme Inhib. 16(3):199-215 (2001).
• Falconi M, Bozzi M, Paci M, Raudino A, Purrello R, Cambria A, Sette M, Cambria MT. Spectroscopic and molecular dynamics simulation studies of the interaction of insulin with glucose. Int J Biol Macromol. Oct 22;29(3):161-8 (2001).
• Falconi M, Cambria MT, Cambria A, Desideri A. Structure and stability of the insulin dimer investigated by molecular dynamics simulation. J Biomol Struct Dyn. Apr;18(5):761-72 (2001).
• Raudino A, Cambria A, Sarpietro MG. Binding of Lipid Vesicles to Protein-Coated Solid Polymer Surfaces: A Model for Cell Adhesion to Artificial Biocompatible Materials. J Colloid Interface Sci. Nov 1;231(1):66 - 73 (2000).
• Cambria A, Raudino A, Geronikaki A, Buemi G, Raciti G, Mazzone P, Guccione S, Ragusa S. Thiazole derivatives as inhibitors of purified bovine liver mitochondrial monoamine oxidase-B: structure-activity relationships and theoretical study. J Enzyme Inhib. 14(4):307-21 (1999).
• Bertino L, Ruffini MC, Copani A, Bruno V, Raciti G, Cambria A, Nicoletti F. Growth conditions influence DNA methylation in cultured cerebellar granule cells. Brain Res Dev Brain Res. Aug 20;95(1):38 - 43 (1996).
• Cambria A, Raudino A, Castelli F, Raciti G, Mazzone P, Buemi G, Pignatello R, Mazzone G. Structure-activity studies on monoamine oxidase inhibitors by calorimetric and quantum mechanical calculations. J. Enzyme Inhib. 10(4):215-229 (1996).
• Raciti G, Mazzone P, Raudino A, Mazzone G, Cambria A. Inhibition of rat liver mitochondrial monoamine oxidase by hydrazine-thiazole derivatives: structure-activity relationships. Bioorg Med Chem. Nov;3(11):1485 - 91 (1995).
• Casabona G, Sturiale L, L'Episcopo MR, Raciti G, Fazzio A, Sarpietro MG, Genazzani AA, Cambria A, Nicoletti F. HPLC analysis of cyclic adenosine diphosphate ribose and adenosine diphosphate ribose: determination of NAD+ metabolites in hippocampal membranes. Ital J Biochem. Sep-Oct;44(5):258-68 (1995).
• Marino M, Galvano M, Cambria A, Polticelli F, Desideri A. Modelling the three-dimensional structure and the electrostatic potential field of two Cu,Zn superoxide dismutase variants from tomato leaves. Protein Eng. Jun;8(6):551-6 (1995).